کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5504108 | 1400214 | 2017 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
FGF2, FGF3 and FGF4 expression pattern during molars odontogenesis in Didelphis albiventris
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کلمات کلیدی
FGF3Didelphis albiventrisT-boxFGF4FGF2FGFPFABSA - BSATbx - TBXbovine serum albumin - آلبومین سرم گاوImmunohistochemistry - ایمونوهیستوشیمیTooth development - توسعه دندانShh - خیرembryonic day - روز جنینیpostnatal day - روز پس از زایمانsonic hedgehog - صدای جیر جیرfibroblast growth factor - فاکتور رشد فیبروبلاستBMP - مدیریت فرایند کسب و کارparaformaldehyde - پارافرمالدهیدBone morphogenetic protein - پروتئین مورفوژنیک استخوان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Odontogenesis is guided by a complex signaling cascade in which several molecules, including FGF2-4, ensure all dental groups development and specificity. Most of the data on odontogenesis derives from rodents, which does not have all dental groups. Didelphis albiventris is an opossum with the closest dentition to humans, and the main odontogenesis stages occur when the newborns are in the pouch. In this study, D. albiventris postnatals were used to characterize the main stages of their molars development; and also to establish FGF2, FGF3 and FGF4 expression pattern. D. albiventris postnatals were processed for histological and indirect immunoperoxidase analysis of the tooth germs. Our results revealed similar dental structures between D. albiventris and mice. However, FGF2, FGF3 and FGF4 expression patterns were observed in a larger number of dental structures, suggesting broader functions for these molecules in this opossum species. The knowledge of the signaling that determinates odontogenesis in an animal model with complete dentition may contribute to the development of therapies for the replacement of lost teeth in humans. This study may also contribute to the implementation of D. albiventris as model for Developmental Biology studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 119, Issue 2, March 2017, Pages 129-141
Journal: Acta Histochemica - Volume 119, Issue 2, March 2017, Pages 129-141
نویسندگان
Íria Gabriela Dias dos Santos, Erika Cristina Jorge, Aline Gonçalves Lio Copola, Bruno Machado Bertassoli, Alfredo Miranda de Goes, Gerluza Aparecida Borges Silva,