کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5504111 1400214 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The possible protective role of pumpkin seed oil in an animal model of acid aspiration pneumonia: Light and electron microscopic study
ترجمه فارسی عنوان
نقش حفاظتی احتمالی روغن دانه کدو در یک مدل حیوانی پنومونی آسپیراسیون اسید: مطالعه میکروسکوپ نور و الکترون
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Aspiration pneumonitis is a common problem occurring in many clinical disorders. Pumpkin seed oil (PO) is a rich source of antioxidants. This work aimed to assess the effect of PO on the lung histopathological changes induced by acid aspiration. Forty male albino rats assigned to four groups were used. Rats of control group were instilled intratracheally with normal saline 2 mL/kg. HCL group instilled with 2 mL/kg of HCL 0.1N, pH 1.25. PO group received pumpkin seed oil (PO) orally (∼1375 mg/kg bw/day) for 7 days. HCL + PO group instilled with 2 mL/kg of HCL 0.1N, pH 1.25 and received PO at the same dose of PO group. Lung tissue samples were processed for light, electron microscopic and immunohistochemical study using anti inducible NO synthase (iNOS). The lung of HCL group demonstrated thickened interalveolar septa, inflammatory cell infiltration and significant increase in the area percent of collagenous fibers and immune expression of iNOS. Ultra structurally, disrupted alveolocapillay membrane, degenerated type II pneumocytes and plentiful alveolar macrophages were evident. PO administration partially attenuated these histological and ultra structural alterations and reduced iNOS immune-expression in lung tissue. In conclusion, PO has a protective effect against HCL aspiration lung injury most probably through its antioxidant activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 119, Issue 2, March 2017, Pages 161-171
نویسندگان
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