کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5514631 1541684 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewStructural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications
ترجمه فارسی عنوان
بررسی تنوع گونه ای پپتیدهای سیکل دریایی و مکانیزم های مولکولی آن برای ضد سرطان، ضد باکتری، ضد قارچی و سایر برنامه های کاربردی بالینی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


- Cyclic peptides and analogue from marine organisms possess potential biological properties.
- Their activities and modes of actions may be different according to their chemical structures.
- Chemical structure, bioactivities, and clinical research of marine cyclic peptides are discussed in this review.

Many cyclic peptides and analogues derived from marine sources are known to possess biological properties, including anticancer, antitumor, antibacterial, antifungal, antiparasitic, anti-inflammation, anti-proliferative, anti-hypertensive, cytotoxic, and antibiotic properties. These compounds demonstrate different activities and modes of action according to their structure such as cyclic oligopeptide, cyclic lipopeptide, cyclic glycopeptide and cyclic depsipeptide. The recent advances in application of the above-mentioned cyclic peptides were reported in dolastatins, soblidotin, didemnin B, aplidine, salinosporamide A, kahalalide F and bryostatin 1 and they are currently in clinical trials. These cyclic peptides are possible novel drugs discovered and developed from marine origin. Literature data concerning the potential properties of marine cyclic peptides were reviewed here, and the structural diversity and biological activities of marine cyclic peptides are discussed in relation to the molecular mechanisms of these marine cyclic peptides.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 95, September 2017, Pages 94-105
نویسندگان
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