کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5516602 1542682 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biotransformation of drospirenone, a contraceptive drug, with Cunninghamella elegans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Biotransformation of drospirenone, a contraceptive drug, with Cunninghamella elegans
چکیده انگلیسی


- Biotransformation of drospirenone by Cunninghamella elegans afforded six compounds.
- Five metabolites were undescribed products in the chemical bibliography.
- Microbial transformation of drospirenone involves oxidation at C-11, -12 and -14.
- Biotransformation of drospirenone is a good tool for addition of CO and OH groups.

Biotransformation of an orally active contraceptive drug, drospirenone (1), by Cunninghamella elegans ATCC 36114 yielded four new metabolites, 6β,7β,15β,16β-dimethylene-3-oxo-14α-hydroxy-17α-pregn-4-ene-21,17-carbolactone (2), 6β,7β,15β,16β-dimethylene-3,11-dioxo-17α-pregn-4-ene-21,17-carbolactone (3), 6β,7β,15β,16β-dimethylene-3,12-dioxo-17α-pregn-4-ene-21,17-carbolactone (4), and 6β,7β,15β,16β-dimethylene-3-oxo-11β,14α-dihydroxy-17α-pregn-4-ene-21,17-carbolactone (5), along with a known metabolite, 6β,7β,15β,16β-dimethylene-3-oxo-11α-dihydroxy-17α-pregn-4-ene-21,17-carbolactone (6). This study provides not only new analogues of orally active contraceptive drug, drospirenone, but also help in understanding the metabolism of this important drug.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 126, October 2017, Pages 30-34
نویسندگان
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