کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5519232 1544102 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expanding biological activities of Ts19 Frag-II toxin: Insights into IL-17 production
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Expanding biological activities of Ts19 Frag-II toxin: Insights into IL-17 production
چکیده انگلیسی


- Ts19 Frag-II induces biochemical alterations in vivo, increasing serum levels of urea, ALT and β-globulin, besides decreasing γ-globulins.
- Ts19 Frag-II induces immunological alterations, increasing NO, IL-6, TNF-α and IL-17, being considered a proinflammatory toxin.
- IL-17 increased-production could be resulted of overall produced-effect of innate immunity or adaptive immunity - Th17 cells.
- This study expanded the biological activities of Ts19 Frag-II, suggesting that this toxin could be contributing to the Ts envenoming.

Tityus serrulatus (Ts) venom is composed of a mixture of toxins presenting diverse biological functions. However, although this venom has been studied over the past three decades, omics analysis revealed that most of its toxins are not identified or their biological activities are unknown. Ts19 Frag-II is included in this group, which function is still uncertain. This study aimed to expand the biological activities of Ts19 Frag-II through in vivo investigation. Our results demonstrates that mice challenged with Ts19 Frag-II presented biochemical alterations, increasing serum levels of urea, ALT and β-globulin, besides decreasing γ-globulins. Moreover, this toxin was also able to induce immunological alterations, increasing NO, IL-6, TNF-α and IL-17, being considered a proinflammatory toxin. The increase of IL-17 was unprecedented regarding Ts toxins and could be a result of the overall produced-effect of cells of innate immunity cells (neutrophils, monocytes, natural killers and lymphoid tissue inducers - LTis) as well as of adaptive immunity (Th17 cells). This study expanded the biological activities of Ts19 Frag-II, suggesting that this toxin could be contributing to the Ts envenoming through alterations of biochemical parameters as well as triggering the inflammatory response.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 134, August 2017, Pages 18-25
نویسندگان
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