کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5523994 1401403 2017 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewEpigenetic basis of cancer health disparities: Looking beyond genetic differences
ترجمه فارسی عنوان
مبنای تجربی مبتنی بر تفاوت های بهداشت سرطان: به دنبال فراتر از تفاوت های ژنتیکی است
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


- Racial health disparities exist among cancer patients.
- Epigenetic basis of cancer health disparities is increasingly being recognized.
- Racially disparate genes are often differentially methylated.
- Regulation involving microRNAs is important for differential cancer racial outcomes.

Despite efforts at various levels, racial health disparities still exist in cancer patients. These inequalities in incidence and/or clinical outcome can only be explained by a multitude of factors, with genetic basis being one of them. Several investigations have provided convincing evidence to support epigenetic regulation of cancer-associated genes, which results in the differential transcriptome and proteome, and may be linked to a pre-disposition of individuals of certain race/ethnicity to early or more aggressive cancers. Recent technological advancements and the ability to quickly analyze whole genome have aided in these efforts, and owing to their relatively easy detection, methylation events are much well-characterized, than the acetylation events, across human populations. The early trend of investigating a pre-determined set of genes for differential epigenetic regulation is paving way for more unbiased screening. This review summarizes our current understanding of the epigenetic events that have been tied to the racial differences in cancer incidence and mortality. A better understanding of the epigenetics of racial diversity holds promise for the design and execution of novel strategies targeting the human epigenome for reducing the disparity gaps.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1868, Issue 1, August 2017, Pages 16-28
نویسندگان
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