Association of TP53 codon 72 and CDH1 genetic polymorphisms with colorectal cancer risk in Bangladeshi population

- This is the first case-control study ever conducted on Bangladeshi colorectal cancer patients in terms of TP53 codon 72 and CDH1 genetic polymorphisms.
- Arg/Pro heterozygosity and Pro/Pro mutant homozygosity at codon 72 of TP53 shows a significant association for colorectal cancer predisposition.
- A allele and combined genotype of C/A and A/A of CDH1 represent an elevated risk of colorectal cancer development.

Till now no pharmacogenetic study of TP53 codon 72 (Arg72Pro) and CDH1 rs16260 (-160C