کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5525029 | 1546544 | 2017 | 7 صفحه PDF | دانلود رایگان |

- Significant association of VEGF mRNA with advanced clinical stages and adenocarcinoma histology in NSCLC.
- VEGF mRNA (âÎCTââ¥10) was found to be associated with NSCLC.
- Quantity of VEGF mRNA can be useful to predict the progression of NSCLC.
Elevated VEGF mRNA (âÎCT) was significantly associated with adenocarcinoma histology (vs squamous) and advanced NSCLC clinical stages in a univariable analysis; however, this association did not remain significant in the multivariable analysis. Of interest, a Kaplan-Meier analysis showed that NSCLC patients with higher VEGF mRNA (âÎCTââ¥10) had a significantly poorer overall survival and shorter postoperative relapse time in adenocarcinoma and in stage III/IV than those with VEGF mRNA of âÎCTâ<10 (Pâ<â0.001). The multivariable analysis confirmed that patients with higher VEGF mRNA levels, as well as with adenocarcinoma and advanced stages, were independent predictors of a poorer survival. However, only the histology of adenocarcinoma remained a significant prognostic factor of a shorter postoperative relapse in the multivariable model. Quantity of VEGF mRNA can be used as a prognosis factor to predict shorter overall survival in patients with NSCLC.
Journal: Cancer Genetics - Volumes 216â217, October 2017, Pages 67-73