کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5525226 1546667 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ArticleDual function of MAZ mediated by FOXF2 in basal-like breast cancer: Promotion of proliferation and suppression of progression
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Original ArticleDual function of MAZ mediated by FOXF2 in basal-like breast cancer: Promotion of proliferation and suppression of progression
چکیده انگلیسی


- MAZ plays dual roles in basal-like breast cancer (BLBC): suppressing progression but promoting proliferation.
- FOXF2 is a transcription target of MAZ and mediates the roles of MAZ.
- MAZ mRNA level, particularly in combination with FOXF2 mRNA level, is a prognostic marker for BLBC patients.

Myc-associated zinc finger protein (MAZ) is a transcription factor with C2H2-type zinc-finger motifs that can bind GC-rich cis-elements. MAZ activates the transcription of some cancer-related genes and represses that of others, suggesting that changes in MAZ expression may play different roles in the development and progression of different types or subtypes of cancers depending on its target genes. However, the functions and mechanisms of MAZ in regulating the carcinogenesis and progression of breast cancer have remained unclear. In the current study, we show that MAZ performs dual function in basal-like breast cancer (BLBC): suppression of aggressiveness and promotion of proliferation. Forkhead box F2 (FOXF2) is a novel transcription target of MAZ and mediates the functions of MAZ. The MAZ mRNA level, particularly in combination with the FOXF2 mRNA level, may serve as a prognostic marker for BLBC patients. Our results indicate that the dual function of the MAZ-FOXF2 axis reflect the pleiotropic nature of multifunctional transcription factors in regulating the different stages of cancer development and progression, which could lead to the complexity of cancer diagnosis and treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 402, 28 August 2017, Pages 142-152
نویسندگان
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