کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5525433 1546682 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mini-reviewScreening and identification of molecular targets for cancer therapy
ترجمه فارسی عنوان
بررسی مینی بررسی و شناسایی اهداف مولکولی برای درمان سرطان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


- Novel targeted therapeutics can help to combat tumor resistance to anti-cancer treatment resulting in recurrence development.
- Carcinoma cell membranes represent a large potential source of druggable therapeutic targets.
- Proteomics is a promising tool for developing potential therapeutic targets.
- Proteome-based evaluation of membrane fractions helps to detect potential therapeutic targets.

In recent decades, targeted therapeutics have significantly improved therapy results in patients with malignant tumors of different origins. However, malignant diseases characterized by aggressiveness and increased capacity for metastatic spread still require basic researchers and clinicians to direct enormous efforts toward the development of novel therapeutic targets. Potential targets should be selected with the clinical endpoint in view; targeted therapeutics can be developed: for use in combination with currently existing therapeutic approaches in order to improve their efficacy; to overcome the treatment resistance of tumor cells and thus protect the patient from recurrence; to repress molecular mechanisms related to immune escape of cancer cells; and to combat the metastatic dissemination of carcinoma cells. Taking into account the specific clinical aim that should be achieved, different strategies and techniques can be proposed to identify the most promising candidate molecules for further development as therapeutic targets. Since cellular membranes contain a large number of druggable molecules, evaluation of the membrane protein profiles of carcinoma cells having different properties can provide a basis for further development of therapeutic targets. This review considers how cellular membranes obtained from different pre-clinical and clinical samples can be used in screening and to identify targets for cancer therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 387, 28 February 2017, Pages 3-9
نویسندگان
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