کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5525645 | 1546676 | 2017 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Mini-reviewYin-yang effect of tumor infiltrating B cells in breast cancer: From mechanism to immunotherapy Mini-reviewYin-yang effect of tumor infiltrating B cells in breast cancer: From mechanism to immunotherapy](/preview/png/5525645.png)
- Breast cancer cells secrete chemokines or antigens, attracting B cell infiltration into the tumor microenvironment.
- B cells enhance the anti-tumor immune effect via secreting antibodies and influencing the Fas/FasL, CXCR4/CXCL12 and perforin pathways, but they also promote the tumor to form a suppressive milieu.
- Tumor infiltrating B cells in breast cancer can sometimes predict the survival and treatment response.
- B cells based immunotherapy maybe a new approach for breast cancer precise treatment.
Breast cancer cells secrete chemokines, such as CXCL13, and antigens or express high endothelial venules, attracting B cells to infiltrate into the tumor microenvironment and play a “yin-yang” effect. They not only enhance the anti-tumor immune effect via secreting antibodies and influencing the Fas/FasL, CXCR4/CXCL12 and perforin pathways but they also promote the tumor to form a suppressive milieu by producing immunomodulatory factors and cytokines or using cell-to-cell education to induce the generation of Tregs or myeloid-derived suppressor cells (MDSCs). Currently, most studies on breast cancer tissue have indicated that B cell infiltration could predict better survival and response to therapy, but two studies have reported opposite results. In a 4T1 tumor-bearing BALB/c mice model, B cell-based immunotherapies were administered, but the efficiency was unstable. Herein, we review the “yin-yang” effect of B cells in breast cancer and discuss B cell-based immunotherapy. B cells are complex aggregates, and breast cancer is a heterogeneous disease. Further studies are urgently required to define the B cell subsets and to discover ways to use B cell-based immunotherapy in breast cancer.
Journal: Cancer Letters - Volume 393, 1 May 2017, Pages 1-7