Original ResearchIntrinsic and extrinsic flaws of the nomogram predicting bone-only metastasis in women with early breast cancer: An external validation study

- Nomogram to identify individuals at higher risk of bone-only metastasis in women with breast cancer.
- Low calibration using the nomogram both for the whole population and when stratified by breast cancer subtype.
- Late-onset bone metastasis is significantly higher in oestrogen receptor-positive women.
- The study showed limitations in the nomogram generalizability to a new and independent patient population.

BackgroundThe recently developed MDACC nomogram purports to predict the risk of bone-only metastasis in women with early breast carcinoma based on five clinical and pathological characteristics. We set out to externally validate and assess its robustness using a tertiary breast cancer centre database.MethodsAll consecutive women treated for early breast cancer in our centre between January 1989 and December 2013 and who had all the nomogram variables documented were eligible for analysis.ResultsWe identified 1255 eligible women for external validation analysis. The median follow-up was 54 months (range: 1-312) and time to initial metastasis 20 months (range: 1-80). The correspondence between the actual bone-only metastasis and the nomogram predictions implied poor calibration of the nomogram in the validation cohort, be it in the whole cohort or when stratified by breast cancer subtype.ConclusionThis external validation study of the MDACC nomogram showed limitations in its generalizability to a new and independent European patient population.