کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5526855 1547064 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ResearchDeterminants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer: A DCOG late-effects study
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Original ResearchDeterminants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer: A DCOG late-effects study
چکیده انگلیسی


- A higher total cumulative dose cisplatin is associated with a higher risk of ototoxicity.
- The risk of ototoxicity increased significantly up to a total cumulative dose cisplatin of 300 mg/m2.
- Children with younger age at diagnosis have an increased risk of ototoxicity after platinum treatment.
- Co-treatment with furosemide is independently associated with ototoxicity.

Platinum-containing chemotherapeutics are efficacious for a variety of pediatric malignancies, nevertheless these drugs can induce ototoxicity. However, ototoxicity data on large cohorts of childhood cancer survivors (CCSs) who received platinum agents, but not cranial irradiation are scarce. Therefore, we have studied the frequency and determinants of ototoxicity in a cross-sectional multicenter CCS cohort, including the role of co-medication since it has been suggested that these play a role in ototoxicity.We have collected treatment data and audiograms from the medical records of CCS treated in the seven pediatric oncology centres in The Netherlands. Ototoxicity was defined as Münster grade ≥2b (>20 dB at ≥4-8 kHz).Four-hundred-fifty-one CCS who received platinum agents, but not cranial irradiation (median age at diagnosis: 4.9 years, range: 0.01-19 years) were included. The overall frequency of ototoxicity was 42%. Ototoxicity was observed in 45% of the cisplatin-treated CCS, in 17% of the carboplatin-treated CCS and in 75% of the CCS that had received both agents. Multivariate analysis showed that younger age at diagnosis (odds ratio [OR]: 0.6, 95% confidence interval [CI]: 0.5-0.6 per 5 years increase); higher total cumulative dose cisplatin (OR: 1.2, 95% CI: 1.2-1.5 per 100 mg/m2 increase); and co-treatment with furosemide (OR: 2.3, 95% CI: 1.4-3.9) were associated with ototoxicity.We conclude that treatment with (higher total cumulative dose of) cisplatin, young age and furosemide co-medication independently are associated with an increased risk of ototoxicity in CCS. Future prospective studies are necessary to confirm the additive risk of co-medication on the development of ototoxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 69, December 2016, Pages 77-85
نویسندگان
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