کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5527479 | 1547725 | 2017 | 5 صفحه PDF | دانلود رایگان |
- Bone marrow Gli1+ cells are heterogeneous at their location within the bone marrow.
- Gli1+ cells provide a central cellular target in bone marrow fibrosis.
- Gli1+ cells act as bone marrow mesenchymal stem cells.
Bone marrow fibrosis is a critical component of primary myelofibrosis in which normal bone marrow tissue and blood-forming cells are gradually replaced with scar tissue. The specific cellular and molecular mechanisms that cause bone marrow fibrosis are not understood. A recent study using state-of-the-art techniques, including in vivo lineage tracing, provides evidence that Gli1+ cells are the cells responsible for fibrotic disease in the bone marrow. Strikingly, genetic depletion of Gli1+ cells rescues bone marrow failure and abolishes myelofibrosis. This work introduces a new central cellular target for bone marrow fibrosis. The knowledge that emerges from this research will be important for the treatment of several malignant and nonmalignant disorders.
Journal: Experimental Hematology - Volume 54, October 2017, Pages 12-16