کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5527513 1401585 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewMechanisms of heparanase inhibitors in cancer therapy
ترجمه فارسی عنوان
بررسی مکانیسم مهارکننده های هپاراآناز در درمان سرطان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


- The role of heparanase and heparanase inhibitors in cancer biology and therapy is reviewed.
- Heparanase promotes invasion, angiogenesis, and tumor metastasis in preclinical models.
- Inhibition of heparanase results in decreased tumor growth and metastasis in vivo.
- Several classes of heparanase inhibitors are presently being investigated.

Heparanase is an endo-β-D-glucuronidase capable of cleaving heparan sulfate side chains contributing to breakdown of the extracellular matrix. Increased expression of heparanase has been observed in numerous malignancies and is associated with a poor prognosis. It has generated significant interest as a potential antineoplastic target because of the multiple roles it plays in tumor growth and metastasis. The protumorigenic effects of heparanase are enhanced by the release of heparan sulfate side chains, with subsequent increase in bioactive fragments and cytokine levels that promote tumor invasion, angiogenesis, and metastasis. Preclinical experiments have found heparanase inhibitors to substantially reduce tumor growth and metastasis, leading to clinical trials with heparan sulfate mimetics. In this review, we examine the role of heparanase in tumor biology and its interaction with heparan surface proteoglycans, specifically syndecan-1, as well as the mechanism of action for heparanase inhibitors developed as antineoplastic therapeutics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Hematology - Volume 44, Issue 11, November 2016, Pages 1002-1012
نویسندگان
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