کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5527561 1401588 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical InvestigationPentraxin-3 levels in graft-versus-host disease during allogeneic hematopoietic stem cell transplantation
ترجمه فارسی عنوان
بررسی بالینی درمورد پنتاکسین-3 در بیماری پروتز پروتئین در برابر پیوند سلول بنیادی خون آلوژنیک
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


- Pentraxin-3 (PTX3) was higher in patients receiving allogeneic transplantation than in patients receiving autologous transplantation or in healthy controls.
- PTX3 levels in acute and chronic graft-versus-host disease (GVHD) were correlated with the severity of GVHD.
- Consistently low PTX3 levels after hematopoietic stem cell transplantation were associated with favorable outcome.

Acute and chronic graft-versus-host-diseases (aGVHD and cGVHD, respectively) are serious complications after hematopoietic stem cell transplantation (HSCT), impairing survival and quality of life. Because the underlying pathomechanism of GVHD is still poorly understood, we investigated the novel inflammatory marker Pentraxin-3 (PTX3) for its potential role in acute and chronic GVHD compared with autologous HSCT and healthy individuals. We collected plasma samples from patients undergoing autologous (n = 12) and allogeneic (n = 28) HSCT and from healthy individuals (n = 15) throughout 7 days before and up to 1 year after HSCT. PTX3 levels in patients with aGVHD were significantly higher (36.4 ± 23.6 ng/mL) than in allogeneic patients without aGVHD (10.4 ± 4.4 ng/mL, p = 0.0001), autologous controls (11.4 ± 6.7 ng/mL, p = 0.001), or healthy individuals (1.9 ± 0.6 ng/mL, p < 0.001). PTX3 levels in patients with cGVHD (13.6 ± 6.3 ng/mL) were significantly lower than in allogeneic patients without cGVHD (25.1 ± 13.8 ng/mL, p = 0.04) and higher than in autologous controls (8.9 ± 7.8 ng/mL, p = 0.07) and healthy individuals (1.9 ± 0.6 ng/mL, p < 0.001). Severity of aGVHD and cGVHD correlated with PTX3 levels. Rising PTX3 levels after HSCT indicated unfavorable outcome. We show that PTX3 levels correlate with the severity of aGVHD, cGVHD, and-with reservations-survival in patients undergoing allogeneic HSCT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Hematology - Volume 44, Issue 10, October 2016, Pages 917-923
نویسندگان
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