کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5527659 | 1401598 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Most deaths from solid cancers occur as a result of secondary metastasis to distant sites. Bone is the most frequent metastatic site for many cancer types and can account for up to 80% of cancer-related deaths in certain tumours. The progression from a discrete solid primary tumour to devastating and painful bone metastases is a complex process involving multiple cell types and steps. There is increasing evidence that modulation of the extracellular matrix plays an important role in the lethal transition from a primary to disseminated metastatic bone tumour. This review provides an overview of the current understanding on the role of role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Bone Oncology - Volume 5, Issue 3, September 2016, Pages 100-103
Journal: Journal of Bone Oncology - Volume 5, Issue 3, September 2016, Pages 100-103
نویسندگان
Alison Gartland, Janine T. Erler, Thomas R. Cox,