Vascular laminins in physiology and pathology

- Lama5 elimination in keratinocytes causes basal keratinocyte hyperproliferation and delayed hair follicle development
- Loss of laminin α5 correlates with elevated dermally derived laminin α2, α4 and tenascin-C
- Laminin α5 loss leads to enhanced immune cell infiltration and altered growth factor loops between epidermis and dermis
- Laminin α5 inhibits basal keratinocyte proliferation and migration and is required for epidermal-dermal intercommunication