کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5529236 1401689 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleADAM 10 expression in primary uveal melanoma as prognostic factor for risk of metastasis
ترجمه فارسی عنوان
اصل مقاله ایده ایدام 10 در ملانوم اولیه یوافع به عنوان عامل پیش آگهی خطر ابتلا به متاستاز
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

Uveal melanoma is the most frequent primary intraocular neoplasm in adults. Although malignant melanoma may be located at any point in the uveal tract, the choroid and ciliary body are more frequent locations than the iris. In the present study, we examined ADAM10 expression levels in primary uveal melanoma both with and without metastasis, and we evaluated their association with other high risk characteristics for metastasis in order to assess if ADAM10 can be used to predict metastasis. This study included a total of 52 patients, 23 men and 29 women, with uveal melanoma. A significantly high expression of ADAM-10 was seen in patients with metastasis (11/13, 84.6%), but not in patients without metastasis (15/39, 38.5%). In conclusion we found that ADAM10 expression was associated with a more rapid metastatic progression confirming its role in uveal melanoma metastasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 212, Issue 11, November 2016, Pages 980-987
نویسندگان
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