کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5529479 1401699 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recurrence patterns in esophagel cancerThe impact of histology on recurrence patterns in esophageal cancer treated with definitive chemoradiotherapy
ترجمه فارسی عنوان
الگوهای عود در سرطان مریضا تاثیر هیستولوژی در الگوهای عود در سرطان مری تحت درمان با شیمی درمانی شیمیدرمانی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

BackgroundTo assess the impact of histology on recurrence patterns and survival outcomes in patients with esophageal cancer (EC) treated with definitive chemoradiotherapy (CRT).MethodsWe analyzed 590 consecutive EC patients who received definitive CRT from 1998 to 2014, including 182 patients (30.8%) with squamous cell carcinoma (SCC) and 408 (69.2%) with adenocarcinoma. Recurrence pattern and timing, survival, and potential prognostic factors were compared.ResultsAfter a median follow-up time of 58.0 months, the SCC group demonstrated a comparable locoregional recurrence rate (42.9% vs. 38.0%, P = 0.264) but a significantly lower distant failure rate (27.5% vs. 48.0%, P < 0.001) than adenocarcinoma group. No significant difference was found in overall survival or locoregional failure-free survival between groups, whereas the SCC group was associated with significantly more favorable recurrence-free survival (P = 0.009) and distant metastasis-free survival (P < 0.001). The adenocarcinoma group had higher hematogenous metastasis rates of bone, brain, and liver, whereas the SCC group had a marginally higher regional recurrence rate. Among patients who received salvage surgery after locoregional recurrence, no significant difference in survival was found between groups (P = 0.12).ConclusionsThe patterns and sites of recurrence, survival outcomes, and prognostic factors were significantly different between esophageal SCC and adenocarcinoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 124, Issue 2, August 2017, Pages 318-324
نویسندگان
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