کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5529493 1401700 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MLC tracking in lung cancerMLC tracking for lung SABR reduces planning target volumes and dose to organs at risk
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
MLC tracking in lung cancerMLC tracking for lung SABR reduces planning target volumes and dose to organs at risk
چکیده انگلیسی

PurposeAssess the dosimetric impact of multi-leaf collimator (MLC) tracking and mid-ventilation (midV) planning compared with the internal target volume (ITV)-based planning approach for lung Stereotactic Ablative Body Radiotherapy (SABR).MethodTen lung SABR patients originally treated with an ITV-based plan were re-planned according to MLC tracking and midV planning schemes. All plans were delivered on a linac to a motion phantom in a simulated treatment with real lung motions. Delivered dose was reconstructed in patient planning scans. ITV-based, tracking and midV regimes were compared at the planning and delivered stages based on PTV volume and dose metrics for the GTV and OAR.ResultsMLC tracking and midV schemes yielded favourable outcomes compared with ITV-based plans. Average reduction in PTV volume was (MLC tracking/MidV) 33.9%/22%. GTV dose coverage performed better with MLC tracking than the other regimes. Reduction in dose to OAR were for the lung (mean lung dose, 0.8 Gy/0.2 Gy), oesophagus (D3 cc, 1.9 Gy/1.4 Gy), great vessels (D10 cc, 3.2 Gy/1.3 Gy), trachea (D4 cc, 1.1 Gy/0.9 Gy), heart (D1 cc, 2.0 Gy/0.5 Gy) and spinal cord (D0.03 cc, 0.5 Gy/−0.1 Gy).ConclusionMLC tracking showed reduction in PTV volume, superior GTV dose coverage and organ dose sparing than MidV and ITV-based strategies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 124, Issue 1, July 2017, Pages 18-24
نویسندگان
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