کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5529590 1401703 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Morbidity of head and neck radiotherapyDiffusion-weighted magnetic resonance imaging for evaluation of salivary gland function in head and neck cancer patients treated with intensity-modulated radiotherapy
ترجمه فارسی عنوان
تداخل رادیوتراپی سر و گردن تصویربرداری رزونانس مغناطیسی با وزن مخصوص برای ارزیابی عملکرد غدد بزاقی در بیماران مبتلا به سرطان سر و گردن تحت درمان با پرتودرمانی شدید مدولاسیون
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

Background and purposesPermanent xerostomia as a result of radiation-induced salivary gland damage remains a common side effect of radiotherapy (RT) of the head and neck. The purpose of this study was to evaluate the usefulness of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing the post-RT salivary gland function in patients with head and neck cancer (HNC).Materials and methodsIn this prospective study, 20 HNC patients scheduled for bilateral neck chemoradiotherapy (CRT) with weekly cisplatin went through diffusion-weighted magnetic resonance imaging (DW-MRI) and salivary gland scintigraphy (SGS) prior to and at a mean of six months after completing the treatment. The changes in apparent diffusion coefficient (ADC) before and after treatment were compared with ejection fraction (EF) measured with SGS and the radiation dose absorbed by the salivary glands.ResultsAs a result of gustatory stimulation with ascorbic acid, the ADC showed a biphasic response with an initial increase and subsequent decrease. This pattern was seen both before and after RT. Post-RT ADC increased as a function of RT dose absorbed by the salivary glands. A moderate statistical correlation between pre- and post-RT ADCs at rest and EF measured with SGS was found.ConclusionsDW-MRI seems a promising tool for detection of physiological and functional changes in major salivary glands after RT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 122, Issue 2, February 2017, Pages 178-184
نویسندگان
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