کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5529806 1401707 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-coplanar trajectories to improve organ at risk sparing in volumetric modulated arc therapy for primary brain tumors
ترجمه فارسی عنوان
مسیرهای غیر همجنسگرایانه برای بهبود ارگان در معرض خطر کم کردن هزینه درمانی مدولاسیون حجمی برای تومورهای مغز اولیه
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

Background and purposeTo evaluate non-coplanar volumetric modulated arc radiotherapy (VMAT) trajectories for organ at risk (OAR) sparing in primary brain tumor radiotherapy.Materials and methodsFifteen patients were planned using coplanar VMAT and compared against non-coplanar VMAT plans for three trajectory optimization techniques. A geometric heuristic technique (GH) combined beam scoring and Dijkstra's algorithm to minimize the importance-weighted sum of OAR volumes irradiated. Fluence optimization was used to perform a local search around coplanar and GH trajectories, producing fluence-based local search (FBLS) and FBLS + GH trajectories respectively.ResultsGH, FBLS, and FBLS + GH trajectories reduced doses to the contralateral globe, optic nerve, hippocampus, temporal lobe, and cochlea. However, FBLS increased dose to the ipsilateral lens, optic nerve and globe. Compared to GH, FBLS + GH increased dose to the ipsilateral temporal lobe and hippocampus, contralateral optics, and the brainstem and body. GH and FBLS + GH trajectories reduced bilateral hippocampi normal tissue complication probability (p = 0.028 and p = 0.043, respectively). All techniques reduced PTV conformity; GH and FBLS + GH trajectories reduced homogeneity but less so for FBLS + GH.ConclusionsThe geometric heuristic technique best spared OARs and reduced normal tissue complication probability, however incorporating fluence information into non-coplanar trajectory optimization maintained PTV homogeneity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 121, Issue 1, October 2016, Pages 124-131
نویسندگان
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