کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5529839 1401708 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prostate cancer radiotherapyStereotactic ablative radiotherapy in the treatment of low and intermediate risk prostate cancer: Is there an optimal dose?
ترجمه فارسی عنوان
رادیوتراپی سرطان پروستات رادیوتراپی انتطارتی استروتاکتیک در درمان سرطان پروستات خطر ابتلا به کم و متوسط: آیا یک دوز بهینه وجود دارد؟
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

PurposeTo investigate if stereotactic ablative radiotherapy (SABR) dose is associated with PSA at 3 years (PSA3y) in the treatment of localized prostate cancer and to explore predictors of late genitourinary (GU) toxicity.Materials and methodsThree prospective trials of SABR were undertaken at our institution: 1) 35 Gy/5 fractions/29 days; 2) 40 Gy/5 fractions/29 days; 3) 40 Gy/5 fractions/11 or 29 days. PSA3y was analyzed as a continuous variable. Toxicity was defined as the worst new toxicity and assessed using the radiation therapy oncology group (RTOG) late morbidity scheme. Univariate and multivariable regression analyses were conducted to assess the association between dose and PSA3y, and to explore predictors of late grade 2+ GU toxicity.ResultsMedian PSA3y was 0.64 (intraquartile range (IQR): 0.41-1.12) and 0.27 (IQR: 0.12-0.55) ng/mL for patients treated with 35 and 40 Gy respectively. A dose of 40 Gy was an independent predictor of lower PSA3y on multivariable analysis (p < 0.001). Dose of 40 Gy (odds ratio (OR): 16.69, 95%CI: 5.78, 48.20, p < 0.001) and higher International Prostate Symptom Score (OR: 1.01, 95%CI: 1.04, 1.16, p = 0.001) predicted for late grade 2+ GU toxicity on multivariable logistic regression.ConclusionsThis analysis suggests that higher SABR dose is associated with lower PSA3y. Strategies to allow safe SABR dose escalation should be further investigated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 123, Issue 3, June 2017, Pages 478-482
نویسندگان
, , , , , , , , , , ,