کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5529989 1401711 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
VMAT+ in liver SBRTVMAT plus a few computer-optimized non-coplanar IMRT beams (VMAT+) tested for liver SBRT
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
VMAT+ in liver SBRTVMAT plus a few computer-optimized non-coplanar IMRT beams (VMAT+) tested for liver SBRT
چکیده انگلیسی

PurposeTo propose a novel treatment approach, designated VMAT+, involving addition of <5 IMRT beams with computer-optimized non-coplanar orientations to VMAT, and evaluate it for liver Stereotactic Body Radiation Therapy (SBRT). VMAT+ is investigated as an alternative for (1) coplanar VMAT and (2) multi-beam non-coplanar treatment.Methods/materialsFor fifteen patients with liver metastases, VMAT+ plans were compared with (1) dual-arc VMAT and (2) 25-beam, non-coplanar treatment with computer-optimized beam orientations (25-NCP). All plans were generated fully automatically for delivery of the highest feasible tumor Biologically Effective Dose (BED). OAR doses, intermediate-dose-spillage, dose-compactness, and measured delivery times were evaluated.ResultsWith VMAT+ the maximum achievable tumor BED was equal to that of 25-NCP. Conversely, VMAT resulted in a lower tumor BED in 5 patients. Compared to VMAT, VMAT+ yielded significant dose reductions in OARs. Intermediate-dose-spillage and dose-compactness were significantly improved by 9.8% and 17.3% (p ≤ 0.002), respectively. Treatment times with VMAT+ were only enhanced by 4.1 min on average, compared to VMAT (8.4 min). Improvements in OAR sparing with 25-NCP, compared to VMAT+, were generally modest and/or statistically insignificant, while delivery times were on average 20.5 min longer.ConclusionsFor liver SBRT, VMAT+ is equivalent to time-consuming treatment with 25 non-coplanar beams in terms of achievable tumor BED. Compared to VMAT, OAR sparing and intermediate-dose-spillage are significantly improved, with minor increase in delivery time.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 123, Issue 1, April 2017, Pages 49-56
نویسندگان
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