کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5529993 | 1401711 | 2017 | 7 صفحه PDF | دانلود رایگان |
PurposeThe purpose of this study was to estimate the uncertainty in voluntary deep-inspiration breath-hold (DIBH) radiotherapy for locally advanced non-small cell lung cancer (NSCLC) patients.MethodsPerpendicular fluoroscopic movies were acquired in free breathing (FB) and DIBH during a course of visually guided DIBH radiotherapy of nine patients with NSCLC. Patients had liquid markers injected in mediastinal lymph nodes and primary tumours. Excursion, systematic- and random errors, and inter-breath-hold position uncertainty were investigated using an image based tracking algorithm.ResultsA mean reduction of 2-6Â mm in marker excursion in DIBH versus FB was seen in the anterior-posterior (AP), left-right (LR) and cranio-caudal (CC) directions. Lymph node motion during DIBH originated from cardiac motion. The systematic- (standard deviation (SD) of all the mean marker positions) and random errors (root-mean-square of the intra-BH SD) during DIBH were 0.5 and 0.3Â mm (AP), 0.5 and 0.3Â mm (LR), 0.8 and 0.4Â mm (CC), respectively. The mean inter-breath-hold shifts were â0.3Â mm (AP), â0.2Â mm (LR), and â0.2Â mm (CC).ConclusionIntra- and inter-breath-hold uncertainty of tumours and lymph nodes were small in visually guided breath-hold radiotherapy of NSCLC. Target motion could be substantially reduced, but not eliminated, using visually guided DIBH.
Journal: Radiotherapy and Oncology - Volume 123, Issue 1, April 2017, Pages 78-84