کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5530304 1401727 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic predisposition to leukemia and other hematologic malignancies
ترجمه فارسی عنوان
استعداد ژنتیکی به لوسمی و سایر بدخیمی های هماتولوژیک
کلمات کلیدی
خطر ژنتیکی، لوسمی خانوادگی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
In this review, we provide an overview of familial myelodysplastic syndromes (MDS)/acute leukemia (AL) and bone marrow failure syndromes, as well as insights into familial myeloproliferative neoplasms (MPNs), familial multiple myeloma (MM), familial Waldenström macroglobulinemia (WM), familial lymphoma, and cancer predisposition syndromes with increased risk of MDS/AL. This field will continue to accelerate as next-generation sequencing (NGS) techniques identify novel predisposition alleles in families with a genetic predisposition to hematologic malignancies. Newly identified predisposition genes continue to inform the field of inherited leukemia and other hematologic malignancies. Current developments in clinical translation include techniques detailing the acquisition of appropriate germline material for patient work-ups, methods for genetic testing, and nuances essential for the treatment and clinical management of patients with a genetic predisposition to hematologic malignancies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Oncology - Volume 43, Issue 5, October 2016, Pages 598-608
نویسندگان
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