Review articleAnalysis of allergic immune responses in humanized mice

- The mechanisms of IgE-mediated allergic diseases are not fully understood.
- The mechanisms of therapeutic approaches are also only partially elucidated.
- The transferability of experimental results from mice to men is limited.
- Humanized mice provide a valuable tool to analyze modulation of allergic diseases.

Nowadays, more than 25% of the population in industrial countries are affected by IgE-mediated (atopic) allergic diseases such as allergic rhinitis, asthma and atopic eczema. Due to intensive research on basis of in vitro studies with human immune cells and different murine in vivo models of allergy fundamental mechanisms of allergic immune responses have been elucidated during the last years. However, human studies are restricted and the immune system of mice differs from the human immune system in several aspects so that the transferability of experimental results from mice to men is limited. Humanized mice represent a new tool to analyze the interaction of human immune cells under physiological conditions as far as possible, particularly to test novel therapeutic strategies. This review summarizes the impact of humanized mouse models for the investigation and treatment of allergic diseases.