کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5531111 | 1549459 | 2017 | 11 صفحه PDF | دانلود رایگان |
- In the endosomal network retromer retrieves cargo away from the degradative pathway.
- Retromer dysfunction has been implicated in Parkinson's disease through different mechanisms.
- These include changes in protein association, protein degradation and mitochondria quality control.
Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.
Journal: Current Opinion in Cell Biology - Volume 47, August 2017, Pages 72-82