کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5531128 | 1549460 | 2017 | 7 صفحه PDF | دانلود رایگان |
- Changes at the chromatin surface initiate nuclear envelope formation and attract membrane from the endoplasmic reticulum.
- Formation of the nascent nuclear envelope depends on membrane remodeling.
- Recent discoveries further inform a mechanism of pore formation as cells exit mitosis.
- Distinct regions of the chromatin disc are associated with different proteins and functions.
Each time a metazoan cell undergoes open mitosis, the nucleus is dismantled in order to partition DNA content to the daughter cells. After chromosomes separate, changes at the chromatin surface usher in reestablishment of nuclear architecture. Proteins destined for the nuclear envelope are attracted to chromatin and concomitantly recruit membrane. As nuclear envelope and protein constituents spread to coat chromatin, distinct regions emerge-some rich in rapid pore formation, others occupied by microtubules that remain attached to kinetochores. Microtubule connections present physical barriers that must be remodeled in order for the nuclear envelope to seal. Regions of the nascent nuclear envelope that are initially characterized by contrasting repertoires of nuclear envelope proteins rapidly coalesce as nuclei expand and enter interphase.
Journal: Current Opinion in Cell Biology - Volume 46, June 2017, Pages 39-45