کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5531163 1549487 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interaction of the innate immune system with positive-strand RNA virus replication organelles
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Interaction of the innate immune system with positive-strand RNA virus replication organelles
چکیده انگلیسی


- All +RNA viruses induce replication organelles to shield viral RNA from innate immune surveillance.
- Recent literature suggests that non-self or aberrant-self membrane structures can be tagged with LC3 or ubiquitin.
- Interferon-induced GTPases then recognize these tags and destroy the membrane structures, thereby exposing PAMPs.
- More research will have to indicate whether this is a general antiviral mechanism affecting +RNA virus infections.

The potential health risks associated with (re-)emerging positive-strand RNA (+RNA) viruses emphasizes the need for understanding host-pathogen interactions for these viruses. The innate immune system forms the first line of defense against pathogenic organisms like these and is responsible for detecting pathogen-associated molecular patterns (PAMPs). Viral RNA is a potent inducer of antiviral innate immune signaling, provoking an antiviral state by directing expression of interferons (IFNs) and pro-inflammatory cytokines. However, +RNA viruses developed various methods to avoid detection and downstream signaling, including isolation of viral RNA replication in membranous viral replication organelles (ROs). These structures therefore play a central role in infection, and consequently, loss of RO integrity might simultaneously result in impaired viral replication and enhanced antiviral signaling. This review summarizes the first indications that the innate immune system indeed has tools to disrupt viral ROs and other non- or aberrant-self membrane structures, and may do this by marking these membranes with proteins such as microtubule-associated protein 1A/1B-light chain 3 (LC3) and ubiquitin, resulting in the recruitment of IFN-inducible GTPases. Further studies should evaluate whether this process forms a general effector mechanism in +RNA virus infection, thereby creating the opportunity for development of novel antiviral therapies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 37, October 2017, Pages 17-27
نویسندگان
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