کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5531168 | 1549487 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytokine expression levels in ALS: A potential link between inflammation and BMAA-triggered protein misfolding
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cytokine expression levels in ALS: A potential link between inflammation and BMAA-triggered protein misfolding Cytokine expression levels in ALS: A potential link between inflammation and BMAA-triggered protein misfolding](/preview/png/5531168.png)
چکیده انگلیسی
Recently, it has been shown that proinflammatory cytokines play a complex and important role in the pathogenesis of many neurological disorders, including amyotrophic lateral sclerosis (ALS). To help facilitate future discoveries and more effective treatment strategies, we highlight the role that both innate and adaptive immune systems play in ALS and summarize the main observations that relate to cytokine expression levels in this disease. Furthermore, we propose a mechanism by which a known neurotoxin, β-N-methylamino-l-alanine (BMAA), may trigger this cytokine expression profile through motor neuron protein misfolding and subsequent NLRP3 (nucleotide-binding domain (NOD)-like receptor protein 3) inflammasome activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 37, October 2017, Pages 81-88
Journal: Cytokine & Growth Factor Reviews - Volume 37, October 2017, Pages 81-88
نویسندگان
Nara Michaelson, Dominic Facciponte, Walter Bradley, Elijah Stommel,