کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5531782 1401814 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of the intrinsic and extrinsic innervation of the gut
ترجمه فارسی عنوان
توسعه بیرونی ذاتی و بیرونی روده
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


- The gastrointestinal tract is innervated by intrinsic and extrinsic neurons.
- Some molecules regulate the development of both intrinsic and extrinsic neurons.
- The extrinsic innervation contributes to both neural wiring and neurogenesis.
- There are multiple cellular origins of enteric neurons and glial cells.

The gastrointestinal (GI) tract is innervated by intrinsic enteric neurons and by extrinsic efferent and afferent nerves. The enteric (intrinsic) nervous system (ENS) in most regions of the gut consists of two main ganglionated layers; myenteric and submucosal ganglia, containing numerous types of enteric neurons and glial cells. Axons arising from the ENS and from extrinsic neurons innervate most layers of the gut wall and regulate many gut functions. The majority of ENS cells are derived from vagal neural crest cells (NCCs), which proliferate, colonize the entire gut, and first populate the myenteric region. After gut colonization by vagal NCCs, the extrinsic nerve fibers reach the GI tract, and Schwann cell precursors (SCPs) enter the gut along the extrinsic nerves. Furthermore, a subpopulation of cells in myenteric ganglia undergoes a radial (inward) migration to form the submucosal plexus, and the intrinsic and extrinsic innervation to the mucosal region develops. Here, we focus on recent progress in understanding the developmental processes that occur after the gut is colonized by vagal ENS precursors, and provide an up-to-date overview of molecular mechanisms regulating the development of the intrinsic and extrinsic innervation of the GI tract.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 417, Issue 2, 15 September 2016, Pages 158-167
نویسندگان
, , , ,