کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5532919 | 1402087 | 2017 | 12 صفحه PDF | دانلود رایگان |
- Fluorescence-based approaches have advanced our understanding of biological noise.
- Recent studies highlight the importance of noise in gene regulation and signaling.
- Cells have evolved methods to circumvent limitations generated by noise.
- In some situations, mechanisms have evolved to generate benefits from noise.
Stochastic fluctuations, termed “noise,” in the level of biological molecules can greatly impact cellular functions. While biological noise can sometimes be detrimental, recent studies have provided an increasing number of examples in which biological noise can be functionally beneficial. Rather than provide an exhaustive review of the growing literature in this field, in this review, we focus on single-cell studies based on quantitative microscopy that have generated a deeper understanding of the sources, characteristics, limitations, and benefits of biological noise. Specifically, we highlight studies showing how noise can help coordinate the expression of multiple downstream target genes, impact the channel capacity of signaling networks, and interact synergistically with oscillatory dynamics to enhance the sensitivity of signal processing. We conclude with a discussion of current challenges and future opportunities.
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Journal: Journal of Molecular Biology - Volume 429, Issue 8, 21 April 2017, Pages 1143-1154