کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5533966 | 1550565 | 2017 | 12 صفحه PDF | دانلود رایگان |
- Germband extension in Drosophila embryos has served as a paradigm for body axis elongation.
- Studies during the last decade have revealed mechanisms driving cell rearrangement.
- Studies have revealed a central role of mechanical forces in germband extension.
Body axis elongation by convergent extension is a conserved developmental process found in all metazoans. Drosophila embryonic germ-band extension is an important morphogenetic process during embryogenesis, by which the length of the germ-band is more than doubled along the anterior-posterior axis. This lengthening is achieved by typical convergent extension, i.e. narrowing the lateral epidermis along the dorsal-ventral axis and simultaneous extension along the anterior-posterior axis. Germ-band extension is largely driven by cell intercalation, whose directionality is determined by the planar polarity of the tissue and ultimately by the anterior-posterior patterning system. In addition, extrinsic tensile forces originating from the invaginating endoderm induce cell shape changes, which transiently contribute to germ-band extension. Here, we review recent progress in understanding of the role of mechanical forces in germ-band extension.
Journal: Mechanisms of Development - Volume 144, Part A, April 2017, Pages 11-22