کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5534155 1550832 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A resistance to thyroid hormone syndrome mutant operates through the target gene repertoire of the wild-type thyroid hormone receptor
ترجمه فارسی عنوان
مقاومت در برابر جهش سندروم هورمون تیروئیدی از طریق پروتئین ژن هدف گیرنده هورمون تیروئید وحشی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


- TR mutations that disrupt proper transcriptional regulation cause human disease.
- An RTH-TRβ1 mutant regulates most of the same genes identified as WT-TRβ1 targets.
- In contrast TRβ1 mutants found in cancers display altered target gene repertoires.
- The gene repertoire of each TR mutant helps define its associated disease syndrome.

Thyroid hormone receptors (TRs) play crucial roles in vertebrates. Wild-type (WT) TRs function primarily as hormone-regulated transcription factors. A human endocrine disease, Resistance to Thyroid Hormone (RTH)-Syndrome, is caused by inheritance of mutant TRs impaired in the proper regulation of target gene expression. To better understand the molecular basis of RTH we compared the target genes regulated by an RTH-TRβ1 mutant (R429Q) to those regulated by WT-TRβ1. With only a few potential exceptions, the vast majority of genes we were able to identify as regulated by the WT-TRβ1, positively or negatively, were also regulated by the RTH-TRβ1 mutant. We conclude that the actions of R429Q-TRβ1 in RTH-Syndrome most likely reflect the reduced hormone affinity observed for this mutant rather than an alteration in target gene repertoire. Our results highlight the importance of target gene specificity in defining the disease phenotype and improve our understanding of how clinical treatments impact RTH-Syndrome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 447, 15 May 2017, Pages 87-97
نویسندگان
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