کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5534216 1550831 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome
ترجمه فارسی عنوان
تمرین بر روی توابع متابولیکی و بافت چربی سفید در مدل های موسوم به لتروزول و دی هیدروتستوسترون زن مبتلا به سندرم تخمدان پلی کیستیک تاثیر می گذارد
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


- Exercise has different effects on letrozole- or dihydrotestosterone-exposed mice.
- Letrozole-exposed mice are more responsive to exercise regarding metabolic aspects.
- Notch signaling pathway in inguinal and mesenteric fat is downregulated by exercise.

Here we hypothesized that exercise in dihydrotestosterone (DHT) or letrozole (LET)-induced polycystic ovary syndrome mouse models improves impaired insulin and glucose metabolism, adipose tissue morphology, and expression of genes related to adipogenesis, lipid metabolism, Notch pathway and browning in inguinal and mesenteric fat. DHT-exposed mice had increased body weight, increased number of large mesenteric adipocytes. LET-exposed mice displayed increased body weight and fat mass, decreased insulin sensitivity, increased frequency of small adipocytes and increased expression of genes related to lipolysis in mesenteric fat. In both models, exercise decreased fat mass and inguinal and mesenteric adipose tissue expression of Notch pathway genes, and restored altered mesenteric adipocytes morphology. In conclusion, exercise restored mesenteric adipocytes morphology in DHT- and LET-exposed mice, and insulin sensitivity and mesenteric expression of lipolysis-related genes in LET-exposed mice. Benefits could be explained by downregulation of Notch, and modulation of browning and lipolysis pathways in the adipose tissue.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 448, 15 June 2017, Pages 66-76
نویسندگان
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