کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5534688 1551267 2017 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Therapeutic potential of agmatine for CNS disorders
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Therapeutic potential of agmatine for CNS disorders
چکیده انگلیسی


- Agmatine protects against inflammation, apoptosis and oxidative stress.
- Agmatine has the ability to stimulate regenerative processes and neurogenesis.
- Agmatine exerts protective effects against several CNS disorders.

Agmatine is a neuromodulator that regulates multiple neurotransmitters and signaling pathways. Several studies have focused on elucidating the mechanisms underlying the neuroprotective effects of this molecule, which seems to be mediated by a reduction in oxidative damage, neuroinflammation, and proapoptotic signaling. Since these events are implicated in acute and chronic excitotoxicity-related disorders (ischemia, epilepsy, traumatic brain injury, spinal cord injury, neurodegenerative, and psychiatric disorders) as well as in nociception, agmatine has been proposed as a therapeutic strategy for the treatment of central nervous system (CNS) disorders. Agmatine also stimulates the expression of trophic factors and adult neurogenesis, contributing to its ability to induce endogenous repair mechanisms. Therefore, considering its wide range of biological effects, this review summarizes the current knowledge about its protective and regenerative properties in the CNS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 108, September 2017, Pages 318-331
نویسندگان
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