Effects of Yohimbine Over Pharmacokinetic and Pharmacodynamic and Behavioral Parameters in Horses Sedated With Detomidine

The aim of this study was to review the safety of the detomidine (DET) in horses and the effects of yohimbine (YOH) over pharmacokinetic, pharmacodynamic, and behavioral parameters in horses sedated with DET. A literature search was made on PubMed (National Center for Biotechnology Information, United States National Library, Bethesda, MD) and SCOPUS (Elsevier Research Intelligence) for studies that had evaluated the effects of DET or YOH on clinics pharmacodynamics and pharmacokinetics parameters in horses plus experimental studies with the effect of YOH on the pharmacokinetics, pharmacodynamics, and behavioral parameters in horses sedated with DET. Additionally, information was obtained from studies where DET or YOH was administered alone or in their combination in treatment of horses. Three investigations described the pharmacokinetics or physiologic effects of YOH when administered after DET to reverse the behavioral and physiologic effects of DET. The studies with DET showed that it was more absorbed when administered intramuscular than when administered sublingual. In those studies, they noted important implications, both from therapeutics and regulatory prospective. They demonstrated intravenously administered DET is effective in sedation with effects on cardiovascular effects.