کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5547826 | 1556148 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cumulative evidence of the low reliability of frozen/thawed pig skin as a model for in vitro percutaneous permeation testing
ترجمه فارسی عنوان
شواهد جمعی بر پایه پایین بودن خواص پوست خرد شده / تلقیح شده به عنوان الگوی آزمایش نفوذ در داخل وریدی
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کلمات کلیدی
نفوذ پوستی، مدل پوست، پوست گوشت خوک، پوست منجمد شده و منجمد،
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
The use of frozen skin after thawing is particularly more convenient for these studies since it is available whenever needed. Even though several researchers have noticed that freezing and then thawing the tissue result in enhancement of drug permeation, many published articles have still described studies using frozen pig skin for bioequivalence and transdermal evaluation of drug products. The aim of this commentary article is therefore to explicitly demonstrate, according to our experience, the low-reliability of the convenient protocol of freezing pig skin for in vitro percutaneous studies. It has been shown in three separate studies using three different drugs that frozen/thawed pig skin had a higher permeability to drugs compared to that obtained by using fresh skin. The results have further demonstrated that the abnormal permeability through frozen pig skin is independent of the effect of different formulations, placing a question mark on the validity of the not freshly-used porcine skin for in vitro penetration studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 102, 1 May 2017, Pages 261-263
Journal: European Journal of Pharmaceutical Sciences - Volume 102, 1 May 2017, Pages 261-263
نویسندگان
Amnon C. Sintov,