کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5547936 | 1556155 | 2016 | 10 صفحه PDF | دانلود رایگان |
The aim of this study is to present the possibility of using of co-processed dry binders for formulation of matrix tablets with drug controlled release. Hydrophilic matrix tablets with tramadol hydrochloride, hypromellose and different co-processed dry binders were prepared by direct compression method. Hypromelloses Methocel⢠K4M Premium CR or Methocel⢠K100M Premium CR were used as controlled release agents and Prosolv® SMCC 90 or Disintequik⢠MCC 25 were used as co-processed dry binders. Homogeneity of the tablets was evaluated using scanning electron microscopy and energy dispersive X-ray microanalysis. The release of tramadol hydrochloride from prepared formulations was studied by dissolution test method. The dissolution profiles obtained were evaluated by non-linear regression analysis, release rate constants and other kinetic parameters were determined. It was found that matrix tablets based on Prosolv® SMCC 90 and Methocel⢠Premium CR cannot control the tramadol release effectively for > 12 h and tablets containing Disintequik⢠MCC 25 and Methocel⢠Premium CR > 8 h.
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Journal: European Journal of Pharmaceutical Sciences - Volume 95, 1 December 2016, Pages 36-45