Effect of coexisting atorvastatin calcium on in vitro uremic-like-toxin adsorption in gastrointestinal tract model solution by spherical carbon adsorbent for chronic renal failure therapy

ObjectivesThe adsorption kinetics of urine-like-toxin indole-3-acetic acid (IA) by spherical carbonaceous adsorbent (SC) was inhibited by competitive effect of atorvastatin calcium (AT).MethodsCompetitive effect of AT on the adsorption behavior of IA by SC was investigated by ultraviolet (UV) absorption/chemometrics method. In order to predict the adsorbed amounts of IA and AT to SC, the calibration models to predict drug concentrations (IA and AT) were obtained based on UV profiles of standard sample solutions by the classical least squares (CLS) method.Key findingsThe IA and AT adsorption behaviors of SC followed first-order kinetics. The drug adsorption kinetic rate constants for IA and AT (kIA and kAT) were obtained for the single- and multiple-drug administrations (SA and MA) by the least-squares method. In the case of the MA, the kIA was 75% suppression by the coexistence of AT, but the kAT was 44% suppression by the IA.ConclusionAdsorption rate to the SC of the IA or AT, respectively, was significantly inhibited by the presence of coexistence drug.

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