Relationship of hard segment concentration in polyurethane-urea elastomers with mechanical, thermal and drug release properties

- Four novel diamines as chain extenders were prepared for the synthesis of PUU elastomers.
- PUU elastomers show sustained release properties in drug delivery applications.
- The PUU elastomers demonstrate good solvent resistance, hardness, and tensile strength.
- A detailed study between the concentration of hard segment and drug release.

The main aim of this research was to study the effects of size and concentration of the hard segments on thermal stability, solvent resistance, hardness and drug delivery applications in polyurethane-urea (PUU) elastomers. Four diamines having different aliphatic chains, were synthesized and used as chain extenders (CE) to synthesize PUU. NCO/OH ratio was changed from 2-2.5 to study the effect of concentration of hard segments. Structure, morphology, thermal stability, hardness, solvent resistance, drug delivery and mechanical properties of polyurethane-urea elastomers were examined by means of fourier transform infrared spectroscopy (FTIR), wide-angle X-ray diffraction (WAXD), thermogravimetric analysis (TGA), shore durometer, UV/Vis spectrophotometer and universal testing machine (UTM) respectively.

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