کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5549282 | 1556687 | 2017 | 9 صفحه PDF | دانلود رایگان |

BackgroundAstragalus extract mixture HT042 is a combination of three standardized extracts from Astragalus membranaceus root, Eleutherococcus senticosus stem, and Phlomis umbrosa root, which has proven to stimulate children's height growth.PurposeThe aim of this study was to demonstrate the safety of HT042 and its three constituent herbs when administered orally.MethodsAcute and sub-chronic oral toxicity studies were conducted using male and female Sprague-Dawley rats. In the acute toxicity study, HT042 and each of the herbs was administered at single doses of up to 5000Â mg/kg. In the 13-week sub-chronic toxicity study, HT042 was administered at repeated doses of up to 4000Â mg/kg/day.ResultsIn the acute toxicity study of HT042 and each of the herbs, no deaths occurred and there was no indication of toxicity, on the basis of clinical signs, body weight, and necropsy findings. In the sub-chronic toxicity study of HT042, there were no deaths and no changes in clinical signs or the findings of ophthalmic examinations. Although there were some treatment-related changes in other findings, these alterations were not considered toxicologically significant because they remained within normal ranges or recovered during the recovery period.ConclusionThe oral approximate lethal doses of HT042 and each of the herbs were >â5000Â mg/kg, and the no-observed-adverse-effect level of HT042 was 4000Â mg/kg/day in male and female rats.
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Journal: Phytomedicine - Volume 32, 15 August 2017, Pages 59-67