کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5554200 1403026 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Radiopharmaceuticals in Acute Porphyria
ترجمه فارسی عنوان
رادیوفارمین در پورفیری حاد
کلمات کلیدی
پورفیری حاد، ایمنی مواد مخدر، پورفری زدن، رادیوتراپی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

PurposeThe acute porphyrias are a group of rare metabolic disorders of the heme biosynthetic pathway. Carriers of the acute porphyria gene are prone to potentially fatal acute attacks, which can be precipitated by drug exposure. It is therefore important to know whether a drug is safe for carriers of the acute porphyria gene. In this study, radiopharmaceuticals were assessed on their porphyrogenicity (ie, the potential of a drug to induce an attack).MethodsThe assessment was conducted by classifying the drugs according to the Thunell model.FindingsFrom 41 radiopharmaceuticals assessed, I-131 norcholesterol, Tc-99m mebrofenin, Tc-99m phytate, Tc-99m sestamibi, and Tl-201 chloride were classified as possibly porphyrogenic.ImplicationsI-131 norcholesterol, Tc-99m mebrofenin, Tc-99m phytate, Tc-99m sestamibi, and Tl-201 chloride should not be prescribed for patients experiencing acute porphyria unless an urgent indication is present and no safer alternative is available. In such cases, potential users should seek advice from a porphyria expert. Preventive measures may also be required.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Therapeutics - Volume 38, Issue 10, October 2016, Pages 2239-2247
نویسندگان
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