کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5554807 1558890 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extracellular matrix scaffolds as a platform for kidney regeneration
ترجمه فارسی عنوان
داربست ماتریکس غیر سلولی به عنوان یک بستر برای بازسازی کلیه
کلمات کلیدی
داروهای احیا کننده، زیست شناسی ارگانیک، کلیه، بازسازی، ماتریکس غیر سلولی، داربست،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی

Chronic and end stage renal disease (ESRD) have reached pandemic levels and pose a substantial public health burden. Unfortunately, available therapies lack efficacy in preventing progression to its end stage phase. Regenerative medicine promises to restore function of diseased organs among which the kidney, through two possible approaches: firstly, the maximization of the innate ability of tissues to repair or regenerate following injury; secondly, the ex vivo bio-fabrication of the organ in question. When regenerative medicine is applied to the setting of chronic or ESRD, it is intuitive that endeavors to improve renal repair, promote nephrogenesis in damaged kidneys, or the de novo engineering of transplantable kidneys, could have a major impact on the current management of this pandemic. Among the different regenerative medicine technologies currently under development, cell-on-scaffold seeding technology (CSST) - involving cells seeded throughout supporting scaffold structures made from biomaterials - is the most favorable candidate in the context of realistic clinical application. In this review, we outline and describe current investigations taking place in the field of CSST as it pertains to the restoration of kidney function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 790, 5 November 2016, Pages 21-27
نویسندگان
, , , , , , , ,