کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5555015 1559624 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Four new neolignans isolated from Eleutherococcus senticosus and their protein tyrosine phosphatase 1B inhibitory activity (PTP1B)
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Four new neolignans isolated from Eleutherococcus senticosus and their protein tyrosine phosphatase 1B inhibitory activity (PTP1B)
چکیده انگلیسی

Four new compounds, erythro-7′E-4-hydroxy-3,3′-dimethoxy-8,5′-oxyneoligna-7′-ene-7,9-diol-9′-al (1), (7S,8S)-4-hydroxy-3,1′,3′-trimethoxy-4′,7-epoxy-8,5′-neolign-9-ol (5), (7S,8S,7′E)-5-hydroxy-3,3′-dimethoxy-4′,7-epoxy-8,5′-neolign-7′-ene-9,9′-diol (6) and (7S,8S,7′E)-5-hydroxy-3,3′,9′-trimethoxy-4′-7-epoxy-8,5′-neolign-7′-ene-9-ol (7). Along with four known compounds (2-4, 8) were isolated from the EtOAc-soluble extract of Eleutherococcus senticosus. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the compounds were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, compounds 1-4 and 6-8 were found to exhibit selective inhibitory activity on PTP1B with IC50 values ranging from 17.2 ± 1.6 to 32.7 ± 1.2 μM.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 121, September 2017, Pages 58-63
نویسندگان
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