کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5555095 1559630 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum
چکیده انگلیسی

Four new polyisoprenylated benzoylphloroglucinol derivatives, hyperscabrones J-M (1-4), were isolated from the air-dried aerial parts of Hypericum scabrum. Their structures were elucidated by spectroscopic methods and were subsequently confirmed by comparing with data of known compounds. The absolute configuration of the bicyclo[3.3.1]nonane-2,4,9-trione core was defined by the experimental and calculated electronic circular dichroism (ECD) spectra. The evaluation of their hepatoprotective activities against paracetamol-induced HepG2 cell damage showed that compounds 2 and 4 exhibited significant hepatoprotection at 10 μM.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 115, December 2016, Pages 128-134
نویسندگان
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