کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5555101 | 1559630 | 2016 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Melaxillines A and B, monoterpenoid indole alkaloids from Melodinus axillaris Melaxillines A and B, monoterpenoid indole alkaloids from Melodinus axillaris](/preview/png/5555101.png)
Two new monoterpenoid indole alkaloids, melaxillines A (1) and B (2), together with four known alkaloids (3-6), were isolated from the roots of Melodinus axillaris. The structures were determined by extensive spectroscopic methods, including 1D and 2D-NMR spectroscopy, high resolution mass spectrometric data, and by comparison to literature data. New compounds 1-2 might be derived from a common precursor (3) by proposing their biogenetic route, and compound 1 represents the first Melodinus alkaloid featuring an ethyl acetate group skeleton at C-18. The anti-inflammatory effects of all the isolated compounds were evaluated by measuring the inhibitory ratios of β-glucuronidase release in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor. Compounds 1-4 showed significant anti-inflammatory activities with IC50 values ranging from 1.51 to 21.56 μM, respectively.
298
Journal: Fitoterapia - Volume 115, December 2016, Pages 173-176