New cytotoxic phloroglucinol derivatives from Agrimonia pilosa

Three new phloroglucinol derivatives, namely agripinol A–C (1–3), were isolated from Agrimonia pilosa Ledeb, along with two known ones (4–5). Their structures were characterized by spectroscopic methods, including MS and NMR spectroscopic techniques. The absolute configurations of the new compounds were unambiguously established by single crystal X-ray diffraction analyses. In the cytotoxicity assay, all compounds exhibited more potent cytotoxic activities against HCT-116, MDA-MB-231 and PC-3, as compared with the positive control fluorouracil.

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